Fig. 1

LqqE1-triggered interspecies quorum quenching in soil microbiome. A Canonical quorum quenching inhibits bacterial virulence. Canonical AHL-quenching proteins AiiA from Bacillus sp. 240B1, MomL from Muricauda olearia, and AiiD from Ralstonia sp. XJ12B could degrade AHLs produced by AHL synthases. To achieve this, these canonical AHL-quenching proteins do not need to interact with AHL synthases. B Novel quorum quenching controls interspecies bacterial killing. OH11 can transport the T4E protein LqqE1 into the cytoplasm of 2P24. LqqE1 does not degrade AHL, but it is able to bind to AHL synthetase through direct protein-protein interactions, causing interference with the recognition of SAM, the substrate required for AHL synthesis, thus achieving naturally occurring quorum quenching and gaining a survival advantage