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Fig. 8 | Phytopathology Research

Fig. 8

From: iTRAQ-based quantitative proteomics reveals a ferroptosis-like programmed cell death in plants infected by a highly virulent tobacco mosaic virus mutant 24A+UPD

Fig. 8

Ferroptosis-like cell death in TMV 24A + UPD infected Nicotiana benthamiana plants. Using iTRAQ, unique DAP’s in the TMV 24A + UPD profile under the ferroptosis and glutathione metabolism pathways were identified. TMV 24A + UPD infected plants showed accelerated cell death symptoms when intracellular iron was increased. Decreasing intracellular iron by employing iron chelators DFO, CPX and silencing of iron storage protein ferritin gene protected the plants from accelerated cell death. We also observed a decrease in TMV 24A + UPD induced cell death when we applied ferroptosis inhibitors ferostatin-1, liprostatin-1. Glutathione peroxidase 4 gene-silenced plants showed enhanced cell death compared to non-silenced control plants

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Phytopathology Research

ISSN: 2524-4167