Fig. 5
From: Gelsolin of insect vectors negatively regulates actin-based tubule motility of plant reoviruses
A proposed model for the ABTM in which gelsolin participates. a The shrinkage of actin filament caused by the depolymerization of actin subunit. The actin filament could be severed by gelsolin at the bared ends, and actin subunits could dissociate from pointed ends. b In the RGDV-infected cells, the up-regulated gelsolin interacted with Pns11 to disassemble the tubules or inhibit tubular formation, ultimately blocking ABTM. Tmod, a capping protein and positive regulator of ABTM, protected the actin filaments from dissociation at the pointed end. c Knockdown of gelsolin allowed for the reassembly of Pns11 and new tubules assembled, leading to the recovery and promotion of ABTM