Table 2 AGO1 protein is targeted by microbes facilitating their colonization
From: ARGONAUTE 1: a node coordinating plant disease resistance with growth and development
Microbes | Host (s) | Target | Function | References |
|---|---|---|---|---|
Cucumber mosaic virus (CMV) | Arabidopsis | AGO1 | CMV 1a protein interacts with the 2b protein and regulates the interaction of 2b protein and AGO1. The 2b protein blocks AGO1 cleavage activity to attenuate RNA silencing and counter host defense | Zhang et al. (2006), Ruiz-Ferrer and Voinnet (2007), Feng et al. (2013), and Watt et al. (2020) |
Poleroviruses | Arabidopsis | AGO1 | Polerovirus-encoded F box protein (P0) targets AGO1 and mediates its degradation in planta | Baumberger et al. (2007), Bortolamiol et al. (2008), and Derrien et al. (2012) |
Tomato (Solanum lycopersicum) | SlAGO1 | P0 mediates SlAGO1 destabilization in tomato | Hendelman et al. (2013) | |
Turnip crinkle virus (TCV) | Arabidopsis | AGO1 | A virus-encoded GW-containing protein (P38) binds directly and specifically to Arabidopsis AGO1 and inhibits its function | Azevedo et al. (2010) |
Sweet potato mild mottle virus (SPMMV) | Arabidopsis | AGO1 | SPMMV P1 targets AGO1 and inhibits RISC activity | Giner et al. (2010) |
Turnip crinkle virus (TCV), ribbgrass mosaic virus (RMV), and cymbidium ringspot virus (CymRSV) | Arabidopsis and Nicotiana benthamiana | AGO1 | Plant viruses mediate miR168 induction followed by the inhibition of the translational capacity of AGO1 mRNA to alleviate its anti-viral function | Várallyay et al. (2010) |
Tomato ringspot virus (ToRSV) | N. benthamiana | NbAGO1 | Tomato ringspot virus coat protein (CP) binds to AGO1 and destabilizes AGO1 | Karran and Sanfacon (2014) |
Turnip yellows virus (TuYV) | Arabidopsis | AGO1 | TuYV P0 associates with AGO1 and mediates the delivery of AGO1 from ER to vacuole followed by the clearance of membrane-bound AGO1 via an ER-derived autophagy degradation pathway | Michaeli et al. (2019) |
Botrytis cinerea | Arabidopsis and tomato | AGO1 | Bc-sRNAs hijack the host RNA interference (RNAi) pathways by binding to AGO1 and selectively silencing the immunity genes of the host | Weiberg et al. (2013) |
Hyaloperonospora arabidopsidis | Arabidopsis | AGO1 | Oomycete sRNAs associate with host AGO1 to target and silence host defense genes for virulence | Dunker et al. (2020) |