Advantages | Description | Implications | Reference |
---|---|---|---|
Speed | Nanopore-based Third-Generation Sequencing accelerates the sequencing process up to 10 times faster | Enables faster responses when rapid platforms are used, reducing economic losses and improving disease management by up to 50% | Goodwin et al. (2016); Jain et al. (2016); Lu et al. (2016); Tedersoo et al. (2021) |
Accuracy | Next-generation sequencing technologies enhance the accuracy of pathogen identification by approximately 20% | Ensures more reliable pathogen identification, leading to effective disease management/control strategies | Piombo et al. (2021) |
Comprehensive genetic information | Next-generation sequencing technologies provide a comprehensive view of a pathogen's genetic makeup | Enhances understanding of pathogen biology, enabling targeted/effective control measures | Köser et al. (2014); Kwong et al. (2015); Quijada et al. (2020) |
Detection of mixed infections & novel pathogens | Identify multiple and novel pathogens in a single sample | Allows enhanced surveillance, improved understanding of interactions, early detection of novel pathogens | Al Rwahnih et al. (2018) |
Automation & scalability | Modern sequencing technologies significantly enhance efficiency by enabling automation and scalability | Enables efficient large-scale monitoring, faster outbreak responses, and significant cost savings due to automation | Chen et al. (2017); Slatko et al. (2018); Martinez et al. (2020) |