Table 2 Role of HTS in uncovering novel and emerging pathogens
Advantages | Description | Implications | Reference |
|---|---|---|---|
Uncovering novel pathogens | HTS uncovers unknown pathogens by detecting and analyzing genetic material directly from infected samples | Facilitates the discovery of new pathogens, providing valuable insights into their biology, ecology, and potential impact | Suminda et al. (2022) |
Identifying new strains/variants | HTS can detect genetic mutations/variations within pathogen populations | Allows for monitoring pathogen evolution, informing disease management strategies to ensure effectiveness | Pandey and Szpara (2019) |
Understanding host–pathogen interactions | HTS enables the analysis of the genetic material of both the host and pathogen, providing a comprehensive view of their interactions | Assists in identifying factors influencing infection, transmission, and host resistance | Karamitros et al. (2021) |